|
HLA-DRB1
|
Xerostomia
|
0.100 |
Biomarker |
HPO |
|
|
|
|
HLA-DRB1
|
Whipple Disease
|
0.020 |
Biomarker |
BEFREE |
The relevance of genetic predisposition in WD is shown by the association with HLA alleles DRB1*13 and DQB1*06 and by the demonstration that, in patients with WD, the cytokine genetic profile is skewed toward a Th2 and Treg response.
|
26154181 |
2015 |
|
HLA-DRB1
|
Whipple Disease
|
0.020 |
GeneticVariation |
BEFREE |
DRB1*13 and DQB1*06 alleles were found to be risk factors in the largest HLA study ever performed in patients with Whipple's disease.
|
19208355 |
2009 |
|
HLA-DRB1
|
West Nile viral infection
|
0.010 |
Biomarker |
BEFREE |
HLA alleles C*08, DRB1*O4:O5, and DQB1*O2 occurred significantly less frequently in WNV than controls (p < 0.05 unadjusted for multiple testing) and DRB1*10:O1 more frequently (p = 0.039).
|
27245377 |
2016 |
|
HLA-DRB1
|
West Nile Fever
|
0.010 |
GeneticVariation |
BEFREE |
Further studies are required of the possibility that HLA C*08, DRB1*O4:O5, and DQB1*O2 are protective alleles and DRB1*10:O1 a "susceptible" allele to WNV infection and the role of secretor status in relation to WNV infection.
|
27245377 |
2016 |
|
HLA-DRB1
|
Weight decreased
|
0.100 |
Biomarker |
HPO |
|
|
|
|
HLA-DRB1
|
Vulvar Lichen Sclerosus
|
0.010 |
GeneticVariation |
BEFREE |
The HLA-A*11, HLA-B*13, HLA-B*15, and HLA-DRB1*12 genotypes were associated with a higher risk of VLS, while the HLA-A*31, HLA-DRB1*01, and HLA-DRB1*03 genotypes were associated with a lower risk of VLS.
|
26662388 |
2015 |
|
HLA-DRB1
|
Vulval intraepithelial neoplasia
|
0.010 |
Biomarker |
BEFREE |
With the exception of HLA-B7 and HLA-DRB1*11, these significant differences were also seen comparative to local HPV-16-positive cervical carcinoma patients (n = 114), suggesting a specific immunogenetic contribution that is independent of HPV-16 infection in high-grade vulval intraepithelial neoplasia.
|
12543794 |
2003 |
|
HLA-DRB1
|
Vogt-Koyanagi-Harada like syndrome
|
0.010 |
Biomarker |
BEFREE |
We report here the case of a HLA-DR4/DRB1*04 patient successfully treated with anti PD-1 for advanced melanoma who developed a systemic immune reaction against melanocytes for whom we discuss a VKH-like syndrome diagnosis in a potentially genetically predisposed patient.
|
28166182 |
2018 |
|
HLA-DRB1
|
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
|
0.040 |
GeneticVariation |
BEFREE |
Furthermore, we also found suggestive epistatic effect between rs2269577 and HLA-DRB1*07 allele on the development of vitiligo (p = 0.033).
|
19543371 |
2009 |
|
HLA-DRB1
|
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
|
0.040 |
Biomarker |
BEFREE |
Our studies have identified three specific alleles, HLA-A*33:01, HLA-B*44:03, and HLA-DRB1*07:01, to be significantly increased in vitiligo patients as compared with controls in both the initial study on North Indians (N=1,404) and the replication study in Gujarat (N=355) cases, establishing their positive association with vitiligo.
|
21833019 |
2012 |
|
HLA-DRB1
|
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
|
0.040 |
Biomarker |
BEFREE |
The DRB1*07 showed significant association with vitiligo in the study population.
|
21241376 |
2011 |
|
HLA-DRB1
|
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
|
0.040 |
GeneticVariation |
BEFREE |
By investigating a group of 39 unrelated adults suffering from vitiligo it was found that alleles HLA-DRB1*0701, -DQB1*0201, and -DPB1*1601 differed in their frequencies in comparison to those observed in the healthy population.
|
9653015 |
1999 |
|
HLA-DRB1
|
Vitiligo
|
0.140 |
GeneticVariation |
BEFREE |
By investigating a group of 39 unrelated adults suffering from vitiligo it was found that alleles HLA-DRB1*0701, -DQB1*0201, and -DPB1*1601 differed in their frequencies in comparison to those observed in the healthy population.
|
9653015 |
1999 |
|
HLA-DRB1
|
Vitiligo
|
0.140 |
Biomarker |
BEFREE |
The DRB1*07 showed significant association with vitiligo in the study population.
|
21241376 |
2011 |
|
HLA-DRB1
|
Vitiligo
|
0.140 |
Biomarker |
BEFREE |
Our studies have identified three specific alleles, HLA-A*33:01, HLA-B*44:03, and HLA-DRB1*07:01, to be significantly increased in vitiligo patients as compared with controls in both the initial study on North Indians (N=1,404) and the replication study in Gujarat (N=355) cases, establishing their positive association with vitiligo.
|
21833019 |
2012 |
|
HLA-DRB1
|
Vitiligo
|
0.140 |
GeneticVariation |
BEFREE |
Furthermore, we also found suggestive epistatic effect between rs2269577 and HLA-DRB1*07 allele on the development of vitiligo (p = 0.033).
|
19543371 |
2009 |
|
HLA-DRB1
|
Vitiligo
|
0.140 |
GeneticVariation |
GWASDB |
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
|
22561518 |
2012 |
|
HLA-DRB1
|
Vitiligo
|
0.140 |
GeneticVariation |
GWASDB |
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.
|
20526339 |
2010 |
|
HLA-DRB1
|
Vitiligo
|
0.140 |
GeneticVariation |
GWASDB |
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
|
20410501 |
2010 |
|
HLA-DRB1
|
Vitamin D Deficiency
|
0.030 |
Biomarker |
BEFREE |
We aimed to study (1) to what extent the influence of low sun exposure on multiple sclerosis (MS) risk is mediated by low vitamin D levels; (2) whether low sun exposure or vitamin D deficiency act synergistically with HLA-DRB1*15:01 and absence of HLA-A*02:01.
|
31844981 |
2019 |
|
HLA-DRB1
|
Vitamin D Deficiency
|
0.030 |
GeneticVariation |
BEFREE |
Then, the interactions of hypovitaminosis D with the other genetic and environmental protective and risk factors, such as the allele HLA DRB1*1501, Epstein-Barr virus infection, obesity, smoking and sexual hormones, are summarized.
|
28619429 |
2017 |
|
HLA-DRB1
|
Vitamin D Deficiency
|
0.030 |
Biomarker |
BEFREE |
To compare vitamin D level-associated single-nucleotide polymorphisms (SNPs) in GC and CYP2R1, multiple sclerosis (MS) risk SNPs in CYP27B1, CYP24A1, and HLA-DRB1*1501, and adolescent exposure to environmental risk factors for hypovitaminosis D, with MS age at onset.
|
26446064 |
2016 |
|
HLA-DRB1
|
Visual auras
|
0.010 |
GeneticVariation |
BEFREE |
An increase in the HLA-DRB1 allele frequency in patients with visual aura has raised greater awareness of the genetic background in migraine.
|
18345414 |
2007 |
|
HLA-DRB1
|
Virus Diseases
|
0.090 |
Biomarker |
BEFREE |
HLA-A, -B, -C, -DRB1 and -DQB1 genotyping were performed in 135 HCV-infected Brazilian patients among which 45 cleared HCV infection (cases) and 90 had persistent viral infection (controls).
|
21914086 |
2011 |